کتاب Regulation of Microbial Metabolism at the Gene and Protein Levels

Chapter 1 4
Human Metabolism as a Controlled Cellular Strategy 4
Metabolism Beyond Pathways: A Regulatory View 4
Cells as Decision Making Metabolic Systems 7
Environmental Signals and Metabolic Responses 10
Why Regulation Matters More Than Flux 14
From Observation to Metabolic Control Design 17
Chapter 2 21
Genetic Architecture of Metabolic Regulation 21
Regulatory Genes as Metabolic Switches 21
Operons and Modular Gene Organization 23
Promoters, Operators, and Regulatory Logic 26
Transcriptional Hierarchies in Metabolic Networks 28
Evolution of Gene Level Metabolic Control 31
Chapter 3 35
Transcriptional Control of Metabolic Pathways 35
Global vs. Pathway Specific Regulators 35
Activators, Repressors, and Dual Regulators 35
Carbon and Nitrogen Control Systems 38
Regulatory Cross Talk Between Pathways 41
Engineering Transcriptional Control Circuits 44
Chapter 4 48
Post Transcriptional Regulation and Metabolic Fine Tuning 48
Regulatory RNAs in Metabolic Control 48
mRNA Stability and Translational Efficiency 50
Riboswitches as Metabolite Sensors 53
RNA Protein Interactions in Metabolic Regulation 56
Synthetic RNA Tools for Metabolic Engineering 58
Chapter 5 64
Protein Level Regulation of Metabolic Activity 64
Enzyme Abundance Versus Enzyme Activity 64
Allosteric Regulation and Feedback Inhibition 66
Isoenzymes and Functional Redundancy 69
Engineering Enzymatic Control Points 71
Chapter 6 74
Post Translational Modifications in Metabolic Regulation 74
Phosphorylation as a Metabolic Control Mechanism 74
Acetylation and Redox Based Modifications 77
Proteolysis and Enzyme Turnover 79
Dynamic Modification Networks 82
Manipulating Post Translational Control 85
References 88