an obstacle, such as the presence of toxic chemicals that make MNPs
challenging to synthesize. Recently, the synthesis of MNPs using plants and
microorganisms (MOs) has been investigated and recognized as an acceptable
and efficacious green pathway as nanoparticles. Their biomedical applications
have been reported in Figure 2. Among the MNPs, the noble metal nanoparticles
(NMNPs), namely Pt, Ag, Au, and their composite analogs have aroused the
interest of investigators due to their new chemical, electronic, optical,
photochemical, and antibacterial capabilities. For instance, nano-silver (Ag) is
applied in clinical healthcare and consumer products because Ag ions have
strong toxicity effects against a wide variety of pathogenic microbes [7, 8].

contamination. During World War I, the silver foil was exploited to protect
wounds from infection [10].
In the 1970s, NASA employed silver tanks to keep drinking water clean on the
spacecraft, and these applications demonstrated the antibiotic and antibacterial
properties of silver. With the discovery of antibiotics in the twentieth century,
less silver was used for medical purposes. Prolonged exposure to silver and
silver compounds induced irreversible spots on the skin and eyes, and the
inability to remove these obstacles caused the exert of silver to be forgotten [11].
During the last century, due to the overuse of antibiotics, some bacteria such as
MRSA and VRSA, which are staphylococci, have become resistant to
antibiotics. The vulnerability of bio-antibiotics as a drug has revived interest in
the antibiotic properties of silver, and with the advancement of nanoscience and
the generation of silver nanoparticles with novel features and morphology, silver
has been able to regain its lost position, and once again, attention is attracted to
silver and its antibacterial features [12-14].
By increasing the surface to volume ratio of silver metal nanoparticles, it is
feasible to change their physical and chemical properties and improve their
effectiveness in the destruction of bacteria. It seems that silver metal
nanoparticles will perform a substantial and forward-looking function in the
battle against microbes in the future [15].