کتاب MiR-Trace-NP AI-Powered ‏PET ‏Nanoprobes ‏Unveiling ‏MicroRNA ‏Paths ‏in ‏Alzheimer’s

Chapter 1 4
The Whispering Genome: Discovering MicroRNA Signatures i 4
The Rise of Post-Genomic Biomarkers in Neurodegeneration 4
MicroRNA Networks as Silent Regulators of Cognitive Decline 7
The Genesis of miR-Trace-NP Concept: From Gene Expression to 12
Early Clues from Molecular Disarray in Alzheimer’s Brains 17
The Promise of Visualizing RNA Pathways in Real Time 22
Chapter 2 28
The Nanoprobe Revolution in Molecular Imaging 28
PET Imaging Beyond the Classical Radiotracer Paradigm 28
Nanoscale Carriers for Precision Neuro-Targeting 33
Hybrid PET-NP Systems and Their Design Logic 39
Radiolabeling Strategies for RNA-Responsive Nanoprobes 45
Interfacing Physics, Chemistry, and Biology in Diagnostic Platforms 50
Chapter 3 57
Engineering the miR-Trace-NP System 57
Nano-Architecture and Core Composition 57
Surface Functionalization for miRNA Recognition 63
Bioconjugation of Aptamers, Peptides, and Antisense Sequences 68
AI-Guided Optimization of Nanoprobe Stability and Binding Kinetics 74
Comparative Evaluation with Traditional Imaging Agents 80
Chapter 4 86
Navigating the Neural Labyrinth: Blood–Brain Barrier Strategies 86
Physiological Gatekeeping of the CNS and Its Challenges 90
Nano-Vehicle Transport Mechanisms Across the BBB 96
Receptor-Mediated Transcytosis and Targeted Delivery Routes 102
Modelling BBB Penetration Efficiency with Deep Learning Tools 107
Safety and Selectivity in Brain-Targeted Nanomedicine 112
Chapter 5 118
Decoding MicroRNA Pathways through AI-Enhanced Imaging 118
Neural Network Algorithms for PET Image Deconvolution 118
Mapping miRNA Expression Patterns to Cognitive Domains 123
Predictive Modelling of Disease Progression Using AI Analytics 128
Integrating Omics Data with Imaging Outputs 133
Dynamic Visualisation of Molecular Crosstalk in the Alzheimer’s Brain 139
Chapter 6 144
Molecular Dialogue Between miRNAs and Alzheimer’s Pathways 144
MiRNA Regulation of Amyloid-β and Tau Protein Cascades 144
Synaptic Plasticity and Gene Silencing Mechanisms 149
Inflammation, Oxidative Stress, and RNA Dysregulation 153
Systemic and Neural Crosstalk in Alzheimer’s Pathophysiology 157
References 162